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Critically, this mechanism is selective for senescent cells because non-senescent cells do not accumulate FOXO4 in PML bodies and do not depend on FOXO4-p53 sequestration for survival

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We then utilized this metabolic interaction to identify a mechanism by which tumor burden can be reduced more effectively in obese mice following orthotopic transplantation of TNBC cells

Regulation of intestinal lipid metabolism: current concepts and relevance to disease